PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Sulfonic chloride-C4-COOMe
0 ImagesCat. No.: HY-W613221CAS No.: 1408058-14-9
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Amino-PEG14-alcohol
0 ImagesCat. No.: HY-133298CAS No.: 34214-89-6Synonyms: H2N-PEG14-OH
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BnO-PEG3-Br
0 ImagesCat. No.: HY-W346506CAS No.: 1239369-02-8
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Propargyl-PEG5-acid (Standard)
0 ImagesCat. No.: HY-101157RCAS No.: 1245823-51-1Propargyl-PEG5-acid (Standard) is the analytical standard of Propargyl-PEG5-acid (HY-101157). This product is intended for research and analytical applications. Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG5-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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tert-Butyl 4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W054209CAS No.: 403802-41-5
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NH2-spiro[3.3]heptane-methyl formate
![NH2-spiro[3.3]heptane-methyl formate](https://file.medchemexpress.com/product_pic/hy-w126577.gif "Click to View NH2-spiro[3.3]heptane-methyl formate Product Detail")
0 ImagesCat. No.: HY-W126577CAS No.: 1808253-04-4
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Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate
0 ImagesCat. No.: HY-W106792CAS No.: 119740-95-3
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trans-Cyclobutane-1,3-dicarboxylic acid
0 ImagesCat. No.: HY-W042294CAS No.: 7439-33-0
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tert-Butyl 2-(2-aminoethyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate dihydrochloride
![tert-Butyl 2-(2-aminoethyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate dihydrochloride](https://file.medchemexpress.com/product_pic/hy-w067912.gif "Click to View tert-Butyl 2-(2-aminoethyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate dihydrochloride Product Detail")
0 ImagesCat. No.: HY-W067912CAS No.: 2173991-85-8
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NH2-C3-PEG2-NH2
0 ImagesCat. No.: HY-W339437CAS No.: 2997-01-5
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1,4-Benzenediethanol
0 ImagesCat. No.: HY-W150669CAS No.: 5140-03-4
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Ethyl hept-6-ynoate
0 ImagesCat. No.: HY-W242243CAS No.: 105339-02-4
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2-(1-Benzylpiperidin-4-yl)acetic acid
0 ImagesCat. No.: HY-W074957CAS No.: 130927-83-2
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Tert-butyl (2-(2-(methylamino)ethoxy)ethyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W492507CAS No.: 1185722-79-5
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tert-Butyl 19-bromononadecanoate
0 ImagesCat. No.: HY-W614706CAS No.: 2428400-73-9
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Benzyl (6-aminohexyl)carbamate
0 ImagesCat. No.: HY-W574894CAS No.: 66095-18-9
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Mal-PEG5-mal
0 ImagesCat. No.: HY-133352CAS No.: 113387-03-4
![tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate oxalate(2:1)](https://file.medchemexpress.com/product_pic/hy-w056055.gif "Click to View tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate oxalate(2:1) Product Detail")
